Other pathological conditions in which anti-CGRP therapeutics could have a beneficial effect include diarrhea caused by bacterial infection, given that the intestinal water secretion and inflammation evoked by Clostridioides difficile toxin A in rats depends on endogenous CGRP (Keates et al., 1998; Bhargava et al., 2013). The gene discussed is CALCA; the disease is bacterial infectious disease.