CALCA and colitis: It is unlikely, however, that inhibition of CGRP signaling is a therapeutic option under inflammatory conditions, given that both exogenous and endogenous CGRP protects from experimentally induced colitis in laboratory animals (Evangelista and Tramontana, 1993; Reinshagen et al., 1998; Mazelin et al., 1999; Clifton et al., 2007; Thompson et al., 2008; Engel et al., 2011; de Jong et al., 2015; Kawashima-Takeda et al., 2017; Yamasaki et al., 2020).