In its medical implication this contention poses a major pharmacological challenge: How can the adverse effect of anti-CGRP therapeutics in the intestine be kept in check without compromising their anti-migraine action which is also thought to take place at a peripheral site outside the blood-brain barrier (Raffaelli and Reuter, 2018; Hargreaves and Olesen, 2019; Johnson et al., 2019; Messlinger and Russo, 2019; Christensen et al., 2020; Noseda et al., 2020)? The gene discussed is CALCA; the disease is migraine disorder.