Importantly, the OM condition was sufficient to induce the expression of pro-angiogenic factors vascular endothelial growth factor A (VEGFA, Figure 2A), angiopoietin 1 (ANGPT1, Figure 2B), hepatocyte growth factor (HGF, Figure 2D), and transforming growth factor-beta (TGFb, Figure 2E). The gene discussed is ANGPT1; the disease is ocular melanoma.