ANGPT1 and diabetic kidney disease: Administration of Ang 1-7 ameliorates diabetic kidney disease in a wide variety of experimental diabetic models, indicating that activation of the counter-regulatory arm of the RAAS is highly beneficial in diabetic nephropathy (Giani et al., 2012; Mori et al., 2014; Zhang et al., 2015; Cassis et al., 2019).