SLC1A2 and Parkinson disease: With regard to PD, two recent pieces of evidence are particularly relevant: (i) The targeted knockdown of EAAT2 in astrocytes causes degeneration of SNc DA neurons in a mouse model of PD (Zhang et al., 2020) and (ii) Exposure of rodents to the PD toxin 6-hydroxydopamine (6-OHDA) causes a downregulation of EAAT2 (Chotibut et al., 2017).