ITCH and esophageal squamous cell carcinoma: The upregulation of circ-ITCH results in ubiquitination and degradation of phosphorylated DVL-2 (disheveled homolog DVL-2) thereby inhibiting the Wnt/ß-Catenin pathway and suggesting the inhibitory effect of circ-ITCH on ESCC (Li et al., 2015b).