Califf, (2018) reported that downregulation of circITGA7 is associated with the progression of colorectal cancer (CRC). Further, the overexpression of circITGA7 resulted in the inhibition of CRC cell proliferation and metastasis both in vitro and in vivo. Kong et al. (2017) reported the circ-SMARCA5 to function as an oncogenic circRNA in CaP via promoting cell proliferation and inhibiting apoptotic cell death. Here, the silencing of circ-SMARCA5 in Du-145 CaP cells resulted in inhibition of cell proliferation and induction of apoptosis (Kong et al., 2017). This evidence concerns the gene SMARCA5 and colorectal cancer.