PITX3 and Parkinson disease: As described in our previous study, we continued to use the triple transgenic mice that overexpressed PD-related α-syn A53T missense mutation in the midbrain dopaminergic neurons with different tau gene dosage from high to low, which were named as Pitx3-A53Tα-Syn × hTau, Pitx3-A53Tα-Syn × Tau+/+, Pitx3-A53Tα-Syn × Tau+/–, and Pitx3-A53Tα-Syn × Tau–/– mice, respectively (Jiao et al., 2020).