Indeed, the activation of both glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) in the heart affects cardiac development, physiology, and pathophysiology (Oakley and Cidlowski, 2015; Richardson et al., 2016), and this is implicated in the development of cardiovascular remodeling during cardiac fibrosis and heart failure (HF) (Brilla and Weber, 1992; Young and Funder, 1996; Weber, 2001). This evidence concerns the gene NR3C1 and heart failure.