We analyzed SCs-related signatures in tumor cells, including target gene expression of the embryonic stem (ES) cell-like transcriptional factors involving NANOG homeobox, octamer-binding transcription factor 4 (OCT4), SRY-related HMG-box2 (SOX2), and MYC, to obtain genetic evidence of the presence of SCs population. The gene discussed is SOX2; the disease is neoplasm.