RHOD and breast cancer: Ideally, we would have liked to examine protein-level expression of the Rho GTPases as well as gene expression, but there are very few small studies on protein levels compared to the large datasets available for normal breast, breast cancer and blood-based transcriptomic profiles, and none to our knowledge for RHOD. Although we could not detect strong evidence of effects for Rho GTPases for the ER− breast cancer subtype, this could be due to a lack of power to detect smaller effect sizes in this cohort.