In the univariate analysis, age ≥ 71 years, diabetes, platelet count < 12.0 × 104/μL, AFP ≥ 4.2 ng/mL, FIB4 index ≥ 2.73, and LSM ≥ 8.4 kPa were identified as factors significantly associated with HCC after SVR. Here, AFP is linked to hepatocellular carcinoma.