NFKB1 and glioblastoma: Because the NF-κB signaling cascade interacts with the signaling cascades initiated by PI3K/Akt14 and the large MAPK family15 and because of literature demonstrating that CD97 signaling increases Erk and MAPK activation in prostate16 and thyroid17 cancers, we investigated these pathways in CD97+ GBM cells.