It interacts with multiple host proteins (such as Prohibitin 1[PHB1], PHB2, and actin-nucleation-promoting WASH protein)140–142 and participates in biological processes such as viral replication, host immune regulation, mitochondrial biogenesis, and endosomal transport.143,144 Nsp2 is therefore a promising novel target for the treatment of COVID-19. The gene discussed is PHB1; the disease is COVID-19.