ALK and non-small cell lung carcinoma: Here we report the results of the first-in-human (FIH) phase 1 study of WX-0593, which was conducted to explore the maximum tolerated dose (MTD), safety, antitumor activity, and pharmacokinetics (PK) of WX-0593 in advanced NSCLC patients with ALK or ROS1 rearrangement.