Similarly, the frequency of CD38+Ly6C+ tissue-resident monocytes (Fig. 3E) and to a better extent than of CD38+Ly6Chigh pro-inflammatory monocytes was reduced after AAV-LAV-BPIFB4 infection, as compared to those of AAV-GFP-aged mice (Fig. 3F). Here, BPIFB4 is linked to infection.