CASP8 and small cell carcinoma: This analysis was further supported by the association of higher CASP8/FLIP(L) mRNA ratios with enhanced sensitivity, which was not only significant in colorectal cancer as expected based on the proteomics data, but also in stomach, breast and bladder cancer, mesothelioma, lung adeno- and small-cell carcinoma and pancreatic cancer (Fig. 3D).