Repeating these analyses in 2 further models, NCI-H28 and NCI-2804, we obtained similar results, with LCL161 and AZD5582 reproducibly synergizing with MEDI3039, but only in the BID-deleted models screened (Supplementary Fig. S5A and S5B); this was further confirmed in a BID-deleted PC9 lung cancer cell line (Supplementary Fig. S5C and S5D). This evidence concerns the gene BID and lung carcinoma.