The same effects on MEDI3039 sensitivity were detected in analogous TNFRSF10B, FADD, CASP8, and BID cRNA KO models derived from two additional rTRAlL-sensitive mesothelioma cell lines H2804 and NCI-H28 (Supplementary Fig. S1C and S1D). Here, FADD is linked to mesothelioma.