PLAT and type 2 diabetes mellitus: Prior to this, stronger observational evidence from a meta-analysis of prospective studies observed a trend for inverse associations between tPA levels and overall CVD risk (RR = 0·82; 95 % CI (0·67, 1·02)) and significant inverse associations with T2D risk (RR = 0·58; 95 % CI (0·46, 0·74), P < 0·001)(82).