CD2 and neoplasm: Clustering analysis and classification based on cellular markers uncovered three different TME cell populations (Microglia/Macrophages, CD2+ immune cells, and OPC-like cells) and three tumor-like cells (NPC-like cells, Astrocyte-like cells, and Cycling cells) (Fig. 1h top-panel, and Table S3), being all these cell populations directly associated with tumor progression and dissemination [25, 50].