These analyses revealed that the resistance to drugs targeting RTK signaling pathways, chromatin acetylation, DNA replication, cell cycle, and mTOR/PI3K signaling pathways was associated with SF3B1 expression, which unveils the potential implication of the dysregulation of SF3B1 in these oncogenic pathways to confer drug resistance in GBM (Fig. S3c; Tables S8–9). This evidence concerns the gene MTOR and glioblastoma.