Alternatively, type 2 diabetes is frequently preceded by a dyslipidemia characterized by hypertriglyceridemia with low HDL cholesterol levels and reduced LDL size [42], which is induced by an increased hepatic secretion of large VLDL particles that interact with the cholesteryl ester transfer protein and hepatic lipase [42, 43]. The gene discussed is CETP; the disease is type 2 diabetes mellitus.