They reported that 1) angiotensin-generating ability in the brain is renin-dependent, 2) DOCA-salt and Ang II hypertension suppress both plasma and brain renin, 3) angiotensinogen protein is undetectable in the brain, despite expression of angiotensinogen mRNA, and 4) the levels of renin/sProrenin are profoundly decreased (>60%) in all brain regions analyzed after washing away blood from the brain vasculature. The gene discussed is REN; the disease is hypertensive disorder.