AGT and hypertensive disorder: Ang II is considered the main biological peptide of the RAS, and its actions, which can lead to the pathogenesis of hypertension through sodium retention [4, 5], vasoconstriction [6], aldosterone synthesis and secretion from the adrenal cortex [7-9], increased sympathetic activity [10, 11] and thirst [12, 13], are attributable to binding of this peptide to angiotensin receptors [14-16].