Fig 6A shows that TDRD3 is unstable and reduced in cells during infections with these enteroviruses. Further, a number of new smaller TDRD3-specific proteins are produced, likely cleavage products. To determine which viral proteinase was involved in TDRD3 cleavage, HEK cell lysates were incubated alone or with purified recombinant CVB3 2Apro which resulted in a decrease or abrogation of intact TDRD3 and similar cleavage products noted during virus infection. Here, TDRD3 is linked to infection.