Likewise, VPA decreases the expression of IL-6 in endothelial cells, a key element of the cytokines storm, the inflammatory event leading to lung infiltrates and pulmonary insufficiency in severe COVID-19, and also decreases the expression of the intercellular adhesion molecule 1(ICAM-1), a cell surface glycoprotein that enhances viral adhesion to the capillary endothelial cells, and facilitates intravascular thrombosis, a severe complication of COVID-19 [21]. This evidence concerns the gene ICAM1 and COVID-19.