In multivariate analysis, the significant predictive factors for 28-day mortality were AD with ALCF (odds ratio [OR], 6.510; 95% confidence interval [CI], 2.844–14.900; p < 0.001), HCC progression as a potential precipitating event (OR, 3.842; 95% CI, 1.846–7.998; p < 0.001), white blood cell level (OR, 1.079; 95% CI, 1.023–1.137; p = 0.005), bilirubin level (OR, 1.140; 95% CI, 1.056–1.231; p = 1.140), albumin level (OR, 0452; 95% CI, 0.237–0.862; p = 0.016), and bacterial infection as a complication defining AD (OR, 0.305; 95% CI, 0.144–0.647; p = 0.002). This evidence concerns the gene ALB and hepatocellular carcinoma.