Multivariate analysis identified the following significant prognostic factors: the prior history of AD (p = 0.001), intermediate-advanced HCC (p < 0.001), receiving potentially curative treatment as the primary treatment (p = 0.001), the occurrence of AD during clinical course (p < 0.001), higher AFP level (p = 0.004), and higher Child-Pugh score (p < 0.001). The gene discussed is AFP; the disease is hepatocellular carcinoma.