Direct sequencing of GRN did not reveal any novel pathogenic variant but led to the identification of five heterozygous missense variants and one in-frame deletion of uncertain significance (VUS) in six patients (S1 Table and S1 Fig): exon 6 c.530G >A (p.Arg177His) in two patients with NPH (V2 and V3); exon 7 c.662G >C (p.Cys221Ser) in a patient with ADD (V4); exon 8 c.827C >T (p.Ala276Val) in a patient with unspecified dementia (V5), exon 13 c.1690C >T (p.Arg564Cys) in a CU participant (V6), and exon 5 c.355_357del (p.Asn119del) in a patient with ADD (V1). The gene discussed is GRN; the disease is dementia.