ADAMDEC1 and Rectal prolapse: Among these differentiation transition genes, Adamdec1 is unique in that it is a secreted metalloproteinase with no other paralogs [90,91], its expression is enriched in intestinal tissues [92], and a single nucleotide polymorphism (SNP) variant (8:24248756 T/C) in this gene locus is associated with rectal prolapse [93,94]).