The univariable MR analysis did not reveal any significant association between blood lipids and advanced PCa risk (HDL; ORIVW = 0.977; 95% CI = [0.905,1.051]; P = 0.552, LDL; ORIVW = 1.067; 95% CI = [0.970,1.74]]; P = 0.191, TG; ORIVW = 1.004; 95% CI = [0.923,1.094]; P = 0.921, Lp(a); ORIVW = 1.064; 95% CI = 0.910,1.245]; P = 0.435, ApoA; ORIVW = 1.001; 95% CI = [0.932,1.073], P = 0.991, ApoB; ORIVW = 0.992; 95% CI = [0.914,1.073], P = 0.837) (Table 1, S6 Table). Here, LPA is linked to posterior cortical atrophy.