The univariable MR analysis showed that genetically predicted HDL (ORIVW = 0.994; 95% CI = [0.942,1.051]; P = 0.825), TG (ORIVW = 1.026; 95% CI = [0.961,1.105]; P = 0.449), apoA (ORIVW = 1.025; 95% CI = [0.970,1.083]; P = 0.372), and apoB (ORIVW = 1.026; 95% CI = 0.961,1.094]; P = 0.411) concentrations were not associated with total PCa risk (S5 Table). Here, LPA is linked to posterior cortical atrophy.