LPA and posterior cortical atrophy: Genetically predicted Lp(a) had an insignificant association on total PCa as estimated from the IVW (ORIVW = 1.066; 95% CI = [0.909,1.249]; P = 0.431) method (Table 1), but the OR of total PCa in the weighted median approach was 1.091 per SD increase in genetically predicted Lp(a) (95% CI = [1.028,1.157]; P = 0.004).