TET2 and leukemia: TET2 is the most abundant TET dioxygenase in HSPCs, and somatic loss-of-function (LOF) mutations of this gene frequently occur in myeloid neoplasia and clonal hematopoiesis of indeterminate potential, a prodromal condition in otherwise healthy elderly individuals associated with a higher rate of progression to leukemia compared with patients without hematopoiesis of indeterminate potential (20).