ALK and neuroblastoma: Entrectinib inhibits phosphorylation of TRKB upon brain-derived neurotrophic factor stimulation in SH-SY5Y NB xenografts35 and inhibits ALK signaling in NB cells.36 Nerve growth factor stimulation of TRKA in PC12 cells caused neurite outgrowth,37 which is abrogated by entrectinib (Figs 5A and 5B), supporting a robust TRKA inhibition.35 To investigate therapeutic efficacy of entrectinib in NB cells, ALK-driven CLB-BAR and CLB-GE cells were used.