PTGS2 and neoplasm: Salvage chemotherapy with topotecan, vincristine, and doxorubicin (TVD)25 was initiated with concomitant cyclooxygenase-2 inhibitor celecoxib.26 At this point, additional genomic and proteomic studies of resected tumor were initiated, during which time the patient completed four courses of TVD and two ensuing courses of temozolomide and topotecan (TOTEM).27