The anaplastic lymphoma kinase (ALK) receptor tyrosine kinase (RTK) is one of the few oncogenes identified in NB.4-8ALK together with MYCN drives NB in a variety of models.9-12 ALK is activated by ALKAL ligands,13-16 and ALKAL2 overexpression increases onset and penetrance of Th-MYCN–driven NB in mice.10ALKAL2 is located together with ALK and MYCN on distal 2p, a region often gained in NB17 and linked to poor prognosis.18,19. The gene discussed is ALK; the disease is neuroblastoma.