The anti-inflammatory effect of PRP injection was confirmed in a study by Ghoz et al. [17], through the immunohistochemical examination to detect NF-κB (nuclear factor kappa-light-chain enhancer of activated B cells), which markedly decreased after PRP injection when compared with its level before treatment; NF-κB is a transcription factor that upregulates many pro-inflammatory cytokines involved in acne pathogenesis. Here, NFKB1 is linked to acne.