Previous studies mostly focussed on ADAM10’s role in extracellular matrix degradation for angiogenesis and metastasis or on its processing of cellular substrates regulating differentiation and cancer cell survival, yet did not consider or reveal any link to PrP (Crawford et al. 2009; Dempsey 2017; Ostalecki et al. 2017; Smith et al. 2020). This evidence concerns the gene PRNP and cancer.