PRNP and Stroke: PrP and its released fragments also seem to play beneficial roles in hypoxic conditions affecting the CNS, such as stroke (Doeppner et al. 2015; Guillot-Sestier et al. 2009; McLennan et al. 2004; Shyu et al. 2005; Spudich et al. 2005; Weise et al. 2006, 2004).