It remains to be studied whether ‘proteolytic shedding’ by ADAM10 and release of putative shed PrPSc seeds into body fluids also plays a role in the ‘environmental shedding’ of prions resulting in the high contagiosity observed in chronic wasting disease (CWD), a prion disease affecting deer, moose, and elk (Bessen et al. 2010; Denkers et al. 2020; Moore et al. 2016; Moreno and Telling 2018; Tennant et al. 2020). The gene discussed is ADAM10; the disease is prion disease.