Since its discovery in the context of unravelling a mysterious group of fatal and transmissible neurodegenerative disease in humans and animals (now collectively termed prion diseases) (Colby and Prusiner 2011; Prusiner 1993), a variety of biological functions and diverse (patho)physiological implications (reviewed in (Aguzzi et al. 2008; Hirsch et al. 2017; Manni et al. 2020; Watts et al. 2018; Wulf et al. 2017)) have been attributed to the evolutionary conserved cellular prion protein (PrP) (Basler et al. 1986; Oesch et al. 1985; Westaway and Prusiner 1986). This evidence concerns the gene PRNP and prion disease.