In this study, we compared cisplatin-resistant and cisplatin-sensitive cell lineages of pluripotent NTERA-2 and NCCIT as well as the nullipotent 2102EP cells (with NCCIT deriving from a TP53 mutated mixed mediastinal GCT) [13, 14] by high-resolution mass spectrometry (MS) combined with stable isotope labelling with amino acids in cell culture (SILAC) [15–18]. Here, TP53 is linked to granular cell tumor.