Likewise, DNA from damaged aortic smooth muscle cells or dying acinar cells during sporadic aortic aneurysm and dissection or acute pancreatitis activates cGAS‒STING signaling in macrophages, which promotes aortic degeneration or pancreatic inflammation (Zhao et al., 2018; Luo et al., 2020). This evidence concerns the gene STING1 and acute pancreatitis.