Consistently, expansion of a hexanucleotide repeat (GGGGCC) in the C9orf72 gene of patients with familial ALS and frontotemporal dementia decreases C9orf72 protein expression and induces type I IFN response in blood-derived macrophages, whole blood, and brain tissue in a STING-dependent manner (McCauley et al., 2020). This evidence concerns the gene C9orf72 and frontotemporal dementia.