STING1 and viral infectious disease: Several E3 ubiquitin ligases, including ring finger protein 5, tripartite motif protein 29 (TRIM29), and TRIM30α, are induced during viral infection, which interact with STING and catalyze its Lys48-linked polyubiquitination for degradation in a proteasome-dependent pathway (Zhong et al., 2009; Wang et al., 2015; Xing et al., 2017).