Disrupting one piece of these regulatory mechanisms leads to the imbalance of cGAS‒STING signaling that induces or aggregates multiple sterile inflammatory diseases, including autoimmune diseases, neurodegenerative diseases, metabolic disorders, and cancers (Bai and Liu, 2019; Motwani et al., 2019b; Paul et al., 2020). The gene discussed is CGAS; the disease is metabolic disease.