NR3C2 and cancer: Our model is supported by several recently reported cancer-associated MR DNA DSB separation-of-function mutants that maintain Mre11 nuclease function while losing the ability to signal the presence of the DNA DSB through ATM or vice versa (Al-Ahmadie et al., 2014; Chansel-Da Cruz et al., 2020; Hohl et al., 2020).