To further explore whether severe fibrosis observed in Ldlr−/− mice is just a result of exacerbated inflammation, a TGF‐β1‐induced PF model was constructed by intratracheally instilling 5 × 108 plaque‐forming units (PFU) adenovirus encoding active transforming growth factor beta‐1 (AdTGF‐β1) into Ldlr−/− and WT mice. This evidence concerns the gene LDLR and pemphigus foliaceus.