Enrichment analysis showed the genes involved in intrinsic apoptotic signalling, cell migration, inflammatory response and ECM (extracellular matrix) were significantly upregulated, whereas genes involved in cell junctions and surfactant homeostasis were downregulated in BLM‐treated Ldlr−/− mice compared with BLM‐treated WT mice (Figure 3H). This evidence concerns the gene LDLR and Bloom syndrome.