Besides, disrupted LDL–LDLR expression was also observed in other three mouse PF models, including BLM‐induced SSc‐PF, DNA Topoisomerase I, Complete Freund's Adjuvant (TopoI‐CFA)‐induced PF and graft‐versus‐host disease (GVHD)‐induced PF (Supporting information Figure S5). This evidence concerns the gene TOP1 and graft versus host disease.