IRF1 is a well‐known transcription factor to regulate tumour cell PD‐L1 expression by binding to CD274 promoter,13, 45, 46 and BRD4 is another key mediator of both tumour cell constitutive and IFN‐γ‐stimulated CD274 transcription.24, 47. The gene discussed is CD274; the disease is neoplasm.