TNF and neoplasm: Specifically, there were 29 differentially expressed PAGs, of which 18 were upregulated (AIM2, CASP1, CASP3, CASP4, CASP5, CASP6, CASP8, GSDMA, GSDMD, GSDME, IL18, IL1B, IL6, NLRC4, NOD1, NOD2, PYCARD and TNF) and 11 were downregulated (CASP9, ELANE, GPX4, GSDMB, NLRP1, NLRP2, PJVK, PLCG1, PRKACA, SCAF11 and TIRAP) in tumour tissues (Figure 1B).