CASP3 and neoplasm: From the aforementioned results, it can be concluded that Zn-NPs ameliorate the oxidative stress induced by Fe-NTA, which is manifested by a decrease in lipid peroxidation, increase of enzymatic and non-enzymatic antioxidant molecules as well as it possesses antitumor promoting activity against Fe-NTA-induced toxicity and carcinogenesis through reduction of tumor cell infiltration and enhancing tumor cell apoptosis which is confirmed histopathologically and biochemically by decreased CEA, increased caspase-3, and decreased level of DNA fragmentation.