Early studies have shown that Galectin-3 plays a pivotal role in autoimmune diseases including autoimmune encephalomyelitis (EAE) [37], rheumatoid arthritis (RA) [38] and systemic sclerosis [39], et al. Karlsen, A.E. et al. identified six polymorphisms in the Galectin-3 gene (LGALS3) and proved that a haplotype containing three SNPs transmitted to unaffected offspring in 257 T1D families increased significantly. This evidence concerns the gene LGALS3 and systemic sclerosis.