The BLM-treated IKBM mice showed a significant down regulation of these genes, compared with BLM-treated WT mice (Col1A1, 1.31 ± 0.04, CTGF, 0.67 ± 0.15, MMP2, 1.14 ± 0.08-, Acta 2, 0.64 ± 0.07 and TGFβ1, 1.15 ± 0.2; P < 0.05) (Fig. 1A–E). Here, CCN2 is linked to Bloom syndrome.