Confirmed HF patients had a significantly lower estimated LVEF % (43 ± 12% vs 54 ± 4%, P < 0.01) and higher NTproBNP (1,883 ± 1,957 vs 748 ± 910 ng/L, P < 0.01) than non-HF patients. This evidence concerns the gene NPPB and hydrops fetalis.