Since TDP-43 is intrinsically linked to both bvFTD and ALS TDP-43 pathology and the fact that TDP-43 is a known transcriptional factor that binds to the TAR element of members of Retroviridae family22, we sought to investigate whether TDP-43 regulates HERV-K transcription. Here, TARDBP is linked to amyotrophic lateral sclerosis.