Considering the prevalence of SLE in the Mexican female population and the genetic heterogeneity among the mestizo subpopulations of Mexico, our objective was to determine the CNV and frequency of rs179008 of the TLR7 gene as genetic risk factors to develop the disease in women with SLE from Yucatán where the Amerindian contribution is mainly of Mayan ancestry [21] and from Central Mexico with different ethnical groups. This evidence concerns the gene TLR7 and systemic lupus erythematosus.