Genetics play a role in the susceptibility to develop SLE, and the number of candidate genes associated with SLE has increased with the analysis of the human genome [9–11]; some are involved in the recognition of nucleic acids and production of interferons (IFN) [12, 13] while others are participating in T and B-cell signaling pathways [14, 15]. This evidence concerns the gene IFNA1 and systemic lupus erythematosus.