In addition, CD25hi Bregs tend to correlate with CTLA-4+ Tregs in healthy controls (Spearman r = 0.284, P = 0.076), but not T1D individuals (Spearman r = 0.007, P = 0.602), as shown in Figures 5(e) and 5(f). The gene discussed is CTLA4; the disease is type 1 diabetes mellitus.