CD40LG and atherosclerosis: On the other hand, studies that immunized Ldlr−/− mice with heat-inactivated S. pneumonia, which significantly induced PC-OxPL recognizing IgM titers due to molecular mimicry, showed that mice immunized were protected against diet-induced steatohepatitis and atherosclerosis after Western-type diet (83, 146), supporting the idea that raising IgM titers toward OxLDL has beneficial effects.