Indeed, NASH has been shown to improve in TLR4 knockout mice receiving a methionine- and choline-deficient (MCD) diet (95), and Ldlr−/− mice receiving an atherogenic diet were found protected from triglyceride accumulation in the liver in the absence of TLR4 (96). The gene discussed is TLR4; the disease is metabolic dysfunction-associated steatohepatitis.