In addition, we previously demonstrated that an increase in B1-derived natural IgM with specificity for OxLDL in Ldlr−/− mice deficient for sialic acid-binding immunoglobulin-like lectin G (Siglec-G) protects against atherosclerosis and steatohepatitis after atherogenic diet, further supporting the protective role of IgM antibodies (110). This evidence concerns the gene CD40LG and atherosclerosis.