Interestingly, vitamin D has anti-inflammatory effects and can reduce anti-EBNA1 IgG antibody concentrations via Vitamin D receptors (VDR), which can have a direct effect on B-cell function and slow the progression of MS (Figure 1C) (Marcucci and Obeidat, 2020; Teymoori-Rad et al., 2021). The gene discussed is VDR; the disease is myeloid sarcoma.