IFNG and myeloid sarcoma: Compared to healthy seropositive individuals, patients with MS have elevated levels of EBNA1-specific CD4+ T cells, which secrete more inflammatory factor IFN-γ after cross-reacting with myelin antigens, which further induces the development of MS (Lunemann et al., 2006; Olsson, 2021; Zdimerova et al., 2021).