Classical neuropathological hallmarks of ALS include ubiquitinated inclusions containing the disordered TDP-43 and FUS (Neumann et al., 2006; Mackenzie et al., 2010; Ikenaka et al., 2020) proteins, although pathology can be heterogeneous with the appearance of other protein aggregates. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.