TARDBP and amyotrophic lateral sclerosis: Aberrant phosphorylation in TDP-43 has been shown to result in increased cytoplasmic mislocalization and aggregation in neuronal cells (Prasad et al., 2019), and multi-site phosphorylated TDP-43 inclusions in the brain is a hallmark of ALS (Neumann et al., 2007; Hasegawa et al., 2008).