Directed studies and unbiased proteome- and transcriptome-wide analyses have shown that Matrin3 interacts with DNA, RNA, and a diverse array of proteins, including the ALS-associated RNA-binding proteins TDP-43 (Boehringer et al., 2017) and FUS (Yamaguchi and Takanashi, 2016). Here, TARDBP is linked to amyotrophic lateral sclerosis.