In Figure 1F, carcinogenic pathways, including calcium signaling pathway, EGFR tyrosine kinase inhibitor resistance, glioma, JAK-STAT signaling pathway, melanoma, non-small cell lung cancer, p53 signaling pathway, pancreatic cancer, the PI3K-Akt signaling pathway, and prostate cancer were markedly enriched by the above genes. This evidence concerns the gene TP53 and melanoma.