ABCG2 and hyperuricemia: In addition, the ATP binding cassette transporter member 2 of subfamily G (ABCG2) is a urate transporter that is primarily expressed in tubules (18), and previous studies have identified that the ABCG2 gene polymorphism causes hyperuricemia and gout (19–21), as well as it revealed the role of renal and extrarenal elimination (22).