In multivariable logistic regression analyses adjusted for BMI, age and PNPLA3 (I148M) genotype, PL behenic acid (22:0) (OR: 1.86, 95% CI: 1.0, 3.45, P < 0.05) was directly associated with liver fibrosis whereas PL 22:6n-3 (OR: 0.45, 95% CI: 0.23, 0.89, P = 0.02), TAG 18:1n-9 (OR: 0.52, 95% CI: 0.28, 0.95, P = 0.03) and TAG 18:1n-9 combined with vaccenic acid (18:1n-7) (18:1) were inversely associated with liver fibrosis. This evidence concerns the gene PNPLA3 and Hepatic fibrosis.