Extracellular vesicles (ECVs) alone (at 5 or 25 μg) partly reduced airway thymic stromal lymphopoietin (TSLP)-associated epithelial damage, epithelial TGF-β1 expression, and subepithelial myofibroblast accumulation in the AAD model and induced myofibroblast accumulation in the BLM model. Here, TSLP is linked to Bloom syndrome.