The THBD 1418T allele in rs1042579 SNP was associated with the lower soluble thrombomodulin levels, both in plasma and in HUVEC-conditioned medium, and with an increase in functional membrane-bound thrombomodulin in HUVEC, explaining the increased APC levels and the reduced venous thromboembolism risk (29). The gene discussed is THBD; the disease is venous thromboembolism.